Thermo Fisher Scientific RNF11 Monoclonal Antibody (4G7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Immunocytochemistry (ICC/IF)

10 µg/mL

-

ELISA (ELISA)

0.1 ng/mL

-

Product Specifications

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

4G7

Immunogen

RNF11 (NP_055187, 65 a.a. approximately 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RNF11,uniProtId:Q9Y3C5-1,ncbiNodeId:9606,antigenRange:65-154,antigenLength:154,antigenImageFileName:H00026994-M01_RNF11_Q9Y3C5-1_House_mouse.svg,antigenImageFileNamePDP:H00026994-M01_RNF11_Q9Y3C5-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: EEQIRIAQRI GLIQHLPKGV YDPGRDGSEK KIRECVICMM DFVYGDPIRF LPCMHIYHLD CIDDWLMRSF TCPSCMEPVD AALLSSYETN

Target Information

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates Lys-63 polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.