Thermo Fisher Scientific PECAM1 Monoclonal Antibody (UMAB30), UltraMAB
PECAM1 단백질을 인식하는 UMAB30 클론의 마우스 단클론 항체. Western blot, IHC, Flow cytometry 등 다양한 분석에 사용 가능. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도 권장. 인간 PECAM1 전체 길이 단백질을 면역원으로 제작.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ChIP assay (ChIP) | Assay-dependent | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB30 |
| Immunogen | Full length human recombinant protein of human PECAM1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor regulating T and B cell signaling through dual ITIM motifs that, upon phosphorylation, recruit protein-tyrosine phosphatases.
CD31 is ubiquitously expressed in the vascular compartment, mainly at cell junctions, and mediates homophilic binding via its N-terminal Ig-like domain.
It plays roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis.
CD31 is a key regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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