Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), APC, eBioscience
인간 CD223(LAG-3)을 인식하는 3DS223H 단클론 항체로, APC 형광체가 결합된 제품입니다. Flow Cytometry에 최적화되어 있으며, 포르말데하이드 고정된 항원을 인식합니다. T 세포 활성 조절 연구 및 면역 분석에 적합합니다.
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- 17-2239-4x (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), APC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested dilution: 5 µL (0.06 µg)/test
View 18 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS223H |
| Immunogen | hCD223-FC PFA 4% |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573185 |
Additional Formats Available
- Alexa Fluor 647
- Alexa Fluor 660
- Alexa Fluor 700
- APC-eFluor 780
- Brilliant UV 395, 563, 661, 737, 805
- Brilliant Violet 421, 480, 605, 650, 711, 786
- eFluor 450, 506
- FITC
- NovaFluor Blue 510, Blue 660-120S, Red 700, Yellow 590, Yellow 610, Yellow 700, Yellow 730
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
This 3DS223H monoclonal antibody recognizes human CD223, also known as Lymphocyte Activation Gene 3 (LAG-3). LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily, homologous to CD4. It binds MHC class II with higher affinity than CD4 and plays a role in negative regulation of T cell activation and proliferation.
Surface expression is observed on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells generally express higher levels than CD4+ T cells. Coexpression with CD49b identifies Type 1 regulatory T cells (Tr1 cells).
- Recognizes formaldehyde-fixed epitope
- Reported for use in flow cytometric analysis
- Pre-titrated and tested on stimulated normal human peripheral blood cells
- Recommended usage: 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
- Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily with homology to CD4. It binds MHC class II with high affinity and regulates T cell activation and proliferation. Expressed on activated T cells, regulatory T cells, and NK cells. CD8+ T cells show higher expression than CD4+. Coexpression with CD49b identifies Tr1 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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