Thermo Fisher Scientific CYP2A6 Monoclonal Antibody (OTI1D2), TrueMAB
CYP2A6 단백질을 표적으로 하는 Mouse IgG2b 단일클론 항체로, WB, IHC(P), Flow Cytometry에 사용 가능. 인간 및 생쥐 반응성. 동결건조 형태로 제공되며, 1 mg/mL 농도. 약물 대사 및 니코틴 대사 연구에 적합.
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Thermo Fisher Scientific CYP2A6 Monoclonal Antibody (OTI1D2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D2 |
| Immunogen | Full length human recombinant protein of human CYP2A6 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CYP2A6 encodes a member of the cytochrome P450 enzyme superfamily. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. It hydroxylates coumarin and metabolizes nicotine, aflatoxin B1, nitrosamines, and several pharmaceuticals.
Certain allelic variants are associated with poor metabolizer phenotypes, leading to inefficient metabolism of coumarin or nicotine.
CYP2A6 is part of a large cluster of cytochrome P450 genes (CYP2A, CYP2B, CYP2F subfamilies) on chromosome 19q. Formerly referred to as CYP2A3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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