Thermo Fisher Scientific Phospho-FADD (Ser194) Polyclonal Antibody
인간 FADD 단백질의 Ser194 인산화 부위를 인식하는 폴리클로날 항체입니다. Western blot 및 IHC(파라핀) 응용에 적합하며, 고순도 액상 형태로 제공됩니다. 세포 사멸 신호 전달 연구에 활용 가능합니다.
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Thermo Fisher Scientific Phospho-FADD (Ser194) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human FADD around the phosphorylation site of Ser194 (A-M-SP-P-M) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554716 |
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, participating in death signaling initiated by these receptors. Interaction with these receptors unmasks the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice indicate its importance in early T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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