Thermo Fisher Scientific PDPK1 Polyclonal Antibody

Thermo Fisher Scientific PDPK1 Polyclonal Antibody

제품 사양

Product Specific Information

Immunogen sequence:
LFARRRQLLL TEGPHLYYVD PVNKVLKGEI PWSQELRPEA KNFKTFFVHT PNRTYYLMDP SGNAHKWCRK IQEVWRQRYQ SHP

Target Information

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop.
PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate.
Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis.
Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-111640_PDPK1_O15530-1_Rabbit.svg)
(이미지 파일명: PA5-111640_PDPK1_O15530-1_Rabbit_PDP.jpeg)