Thermo Fisher Scientific PDPK1 Polyclonal Antibody
Rabbit polyclonal antibody against human PDPK1 for research use. Targets PDPK1 involved in AGC kinase activation and metabolic signaling. Supplied as unconjugated liquid form, stored at 4°C short term or -20°C long term. Suitable for studies on insulin...
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Thermo Fisher Scientific PDPK1 Polyclonal Antibody
제품 사양
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human PDPK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857050 |
Product Specific Information
Immunogen sequence:
LFARRRQLLL TEGPHLYYVD PVNKVLKGEI PWSQELRPEA KNFKTFFVHT PNRTYYLMDP SGNAHKWCRK IQEVWRQRYQ SHP
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop.
PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate.
Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis.
Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-111640_PDPK1_O15530-1_Rabbit.svg)
(이미지 파일명: PA5-111640_PDPK1_O15530-1_Rabbit_PDP.jpeg)
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