Thermo Fisher Scientific TDP1 Polyclonal Antibody
Rabbit polyclonal antibody against human TDP1, validated for ICC/IF. Recognizes recombinant human TDP1 protein. Supplied as liquid form in PBS with 40% glycerol. Suitable for DNA repair and topoisomerase I studies. For research use only.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TDP1. Recombinant protein control fragment (Product #RP-105529) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664934 |
Product Specific Information
Immunogen sequence:
STSSLLCARQG AANEPRYTCS EAQKAAHKRK ISPVKFSNTD SVLPPKRQKS GSQEDLGWCL SSSDDELQPE M
Highest antigen sequence identity to the following orthologs:
- Mouse: 65%
- Rat: 72%
Target Information
The protein encoded by this gene is involved in repairing stalled topoisomerase I–DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3′ phosphate of DNA. It may also remove glycolate from single-stranded DNA containing 3′ phosphoglycolate, suggesting a role in repair of free-radical–mediated DNA double-strand breaks.
This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with spinocerebellar ataxia with axonal neuropathy (SCAN1). Two major transcript variants encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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