Thermo Fisher Scientific ADAM17 Polyclonal Antibody
ADAM17 단백질을 표적하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체입니다. Western blot 및 IHC(P) 등에 사용 가능하며, 인간에 반응하고 마우스 및 랫트에서도 예측 반응합니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific ADAM17 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids LQRQNRVDSKETEC (aa 811–824) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2223543 |
Product Specific Information
- Predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA with antibody detection limit dilution of 32,000.
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and other cell-surface proteins such as:
- p75 TNF-receptor
- Interleukin receptor type II
- p55 TNF-receptor
- Transforming growth factor-alpha
- L-selectin
- Growth hormone receptor
- MUC1
- Amyloid precursor protein
ADAM17 acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the ADAM17 gene can result in inflammatory skin and bowel disease, neonatal 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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