Thermo Fisher Scientific DNER Polyclonal Antibody
DNER 단백질을 검출하는 Rabbit Polyclonal Antibody로 사람, 생쥐, 랫트 시료에 반응합니다. Western blot에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C 단기, -20°C 장기 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human DNER |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553984 |
Product Specific Information
- Detects endogenous DNER protein (~70 kDa).
- Purity >95% by SDS-PAGE.
Target Information
DNER (Delta-notch-like EGF-related receptor) is a neuron-specific, atypical Notch ligand expressed in dendrites and neuronal cell bodies throughout the central nervous system. It contains ten extracellular EGF-like domains homologous to those of the Notch ligand Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells and mediates neuron-glia interaction during astrocytogenesis via direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This activates a Deltex-dependent Notch signaling pathway in Bergmann glia, regulating their morphogenesis. DNER is essential for the functional and morphological maturation of Bergmann glia; knockout mice show motor discoordination and cerebellar morphogenesis defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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