Thermo Fisher Scientific SSB1 Polyclonal Antibody
Thermo Fisher Scientific의 SSB1 폴리클로날 항체는 인간 단일가닥 DNA 결합 단백질 1을 인식합니다. WB, IHC, IP 등에 사용 가능하며, 비결합 상태의 액상 형태로 제공됩니다. DNA 손상 반응 및 복구 연구에 적합하며 4°C에서 보관합니다.
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Thermo Fisher Scientific SSB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 161 and 211 of Human single-stranded DNA-binding protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for human tissues, and citrate buffer pH 6.0 for mouse tissues.
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine.
Target Information
SSB1 is a component of the SOSS complex, which functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint activation.
In the SOSS complex, SSB1 acts as a sensor of single-stranded DNA, particularly binding to polypyrimidines.
The complex associates with DNA lesions and influences various endpoints in the cellular DNA damage response, including cell-cycle checkpoint activation, recombinational repair, and genomic stability maintenance.
SSB1 is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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