Thermo Fisher Scientific Phospho-E2F1 (Thr433) Polyclonal Antibody
E2F1 단백질의 Thr433 인산화 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 인간과 마우스 시료에서 반응합니다. 고순도 정제된 액상 형태로 안정적인 신호 재현성을 제공합니다.
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Thermo Fisher Scientific Phospho-E2F1 (Thr433) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human E2F1 (Accession Q01094), corresponding to amino acid residues around phosphorylated Thr433 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816422 |
Product Specific Information
Antibody detects endogenous levels of E2F1 only when phosphorylated at Threonine 433.
Target Information
The protein encoded by this gene is a member of the E2F family of transcription factors.
The E2F family plays a crucial role in the control of the cell cycle and the action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain conserved domains including:
- DNA binding domain
- Dimerization domain (interacts with DP proteins)
- Transactivation domain enriched in acidic amino acids
- Tumor suppressor protein association domain (within the transactivation domain)
E2F1, along with E2F2 and E2F3, has an additional cyclin binding domain.
This protein binds preferentially to retinoblastoma protein (pRB) in a cell-cycle dependent manner and can mediate both cell proliferation and p53-dependent/independent apoptosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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