Thermo Fisher Scientific TRAF4 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Protein sequence:

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV IPCPNRCPMK LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGMC PQESVYCENK CGARMMRRLL AQHATSECPK RTQPCTYCTK EFVFDTIQSH QYQCPRLPVA CPNQCGVGTV AREDLPGHLK DSCNTALVLC PFKDSGCKHR CPKLAMARHV EESVKPHLAM MCALVSRQRQ ELQELRRELE ELSVGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG THLSLYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA AVELPRKILS

Target Information

The tumor necrosis factor (TNF) receptor superfamily consists of type I integral membrane glycoproteins with cystine-rich extracellular domains. Members include TNF-RI, TNF-RII, and CD40. Ligands for these receptors can be secreted proteins (e.g., TNF) or membrane proteins (e.g., CD40L). Activation of TNF-R or CD40 induces nuclear translocation of NFκB. TRAF (TNF receptor-associated factor) family members mediate this process. Four members—TRAF1, TRAF2, TRAF3, and TRAF4—have been identified. TRAF4, also known as CART1, is specifically expressed in breast carcinomas and localized to the nucleus in such tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.