Thermo Fisher Scientific AKAP12 Monoclonal Antibody (3C3)
AKAP12 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(3C3). Western blot과 ELISA에 사용 가능하며, 인간 시료에 반응. PBS 용액 상태로 제공되며 보존제 무첨가. 연구용으로만 사용 가능.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C3 |
| Immunogen | AKAP12 (NP_005091, 1675–1782 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
VPEDDGHALL AERIEKSLVE PKEDEKGDDV DDPENQNSAL ADTDASGGLT
KESPDTNGPK QKEKEDAQEV ELQEGKVHSE SDKAITPQAQ EELQKQERES AKSELTESTarget Information
A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that bind to the regulatory subunit of protein kinase A (PKA) and localize the holoenzyme to specific cellular regions.
The AKAP12 gene encodes a member of this family, expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells.
It associates with kinases A and C and phosphatase, serving as a scaffold protein in signal transduction.
AKAP12 and RII PKA colocalize at the cell periphery, and this protein is related to cell growth.
Antibodies to this protein can be produced by patients with myasthenia gravis.
Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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