Thermo Fisher Scientific CX3CL1 Recombinant Rabbit Monoclonal Antibody (022)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody specifically recognizes Human Fractalkine/CX3CL1.

Target Information

Chemokines are proteins involved in leukocyte trafficking during immune surveillance and inflammation. CX3CL1 (Fractalkine) is a CX3C chemokine that mediates leukocyte adhesion and migration via membrane-bound and soluble forms.
It can suppress production of nitric oxide, interleukin-6, and TNF-α in activated microglia and neuronal cells, suggesting a role in neuroprotection.
Its receptor, CX3CR1, also acts as a co-receptor for HIV-1 and HIV-2 envelope fusion and infection, which can be inhibited by CX3CL1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.