Thermo Fisher Scientific HLA-DR Monoclonal Antibody (L243), FITC, eBioscience
HLA-DR 단백질을 인식하는 L243 클론의 FITC 결합 단일클론 항체로, 인간 및 비인간 영장류 시료에 반응합니다. Flow Cytometry 분석에 최적화되어 있으며, 488 nm 청색 레이저에서 520 nm 형광 방출을 제공합니다. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific HLA-DR Monoclonal Antibody (L243), FITC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Cynomolgus monkey, Human, Non-human primate, Rhesus monkey |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | L243 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572541 |
Available Formats
- Alexa Fluor 700
- APC
- APC-eFluor 780
- eFluor 450
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Request custom conjugation available
Product Specific Information
The L243 monoclonal antibody recognizes human major histocompatibility complex (MHC) class II, HLA-DR, expressed on antigen-presenting cells such as B cells, monocytes, macrophages, dendritic cells, and activated T cells.
HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits, crucial for peptide presentation to CD4+ T lymphocytes.
The L243 antibody binds a distinct epitope compared to LN3 and does not cross-block.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated for flow cytometry of normal human peripheral blood cells
- Recommended Usage: 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
- Excitation / Emission: 488 nm / 520 nm (Blue Laser)
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
HLA-DR is a transmembrane glycoprotein consisting of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The DRA gene contains 5 exons encoding leader peptide, extracellular domains, transmembrane region, and cytoplasmic tail.
DRA is non-polymorphic, while DRB contains polymorphisms determining peptide binding specificity.
Hundreds of DRB1 alleles are known, routinely typed for bone marrow and kidney transplantation.
HLA-DR is expressed mainly on antigen-presenting cells (B lymphocytes, monocytes, macrophages, thymic epithelial cells, activated T lymphocytes).
MHC class II molecules (DR, DQ, DP) present processed peptides to T-helper cells, initiating immune responses.
HLA and MHC antibodies are essential in Immunopeptidomics, aiding neoantigen identification via LC-MS/MS.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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