Thermo Fisher Scientific CD63 Recombinant Rabbit Monoclonal Antibody (013)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select the best candidates.

Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Rat CD63.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family found in late endosomes, lysosomes, and secretory vesicles of various cell types. It is also present in the plasma membrane following cell activation and serves as a widely used basophil activation marker.

CD63 interacts with integrins, affects phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and regulation of ROMK1 channels. It also functions as a T-cell costimulation molecule. Expression of CD63 can help predict prognosis in early-stage carcinomas.

CD63 is expressed on activated platelets and translocated to the plasma membrane after activation. It is also present in monocytes and macrophages, with weak expression on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen ME491 and platelet antigen PTLGP40.

Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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