Thermo Fisher Scientific ADSL Polyclonal Antibody
Thermo Fisher Scientific의 ADSL Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 토끼 유래 IgG 항체입니다. Western blot 및 IHC(P) 실험에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 보관 권장.
- 카탈로그번호
- PA529964
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 189–466 of Human ASL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% Thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547438 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2
- Predicted reactivity: Mouse (97%), Rat (95%), Zebrafish (84%), Xenopus laevis (90%), Pig (97%), Chicken (91%), Chimpanzee (98%), Bovine (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL, or ASASE, is a 484 amino acid protein involved in purine biosynthesis and AMP formation from inosine monophosphate.
ADSL catalyzes two key reactions in AMP biosynthesis:
- Removal of fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to yield aminoimidazole carboxamide ribotide (AICA)
- Removal of fumarate from adenylosuccinate to yield AMP
Defects in the ADSL gene cause adenylosuccinase deficiency, an autosomal recessive disorder characterized by epilepsy, growth retardation, and muscular wasting.
Multiple isoforms of ADSL exist due to alternative splicing events.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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