Thermo Fisher Scientific TFF2 Polyclonal Antibody
Mouse 및 Rat 반응성을 가진 Rabbit Polyclonal TFF2 항체. Western Blot과 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제된 동결건조 형태. 위장 점막 보호 및 재생 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived rat TFF2 recombinant protein (Position: E24–Y129) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2747227 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Trefoil peptides are protease-resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds forming the trefoil motif (P-domain).
SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, functions to inhibit gastrointestinal motility and gastric acid secretion. SP may act as a structural component of gastric mucus by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
Downregulation of SP expression is associated with primary gastric cancer, and progressive loss of this protein is likely involved in early stages of gastric carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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