Thermo Fisher Scientific CD14 Monoclonal Antibody (OTI3D6), TrueMAB
인간 CD14 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot과 유세포분석에 적합합니다. 동결건조 형태로 제공되며, 보존제가 포함되지 않습니다. 연구용으로만 사용되며, 재구성 및 결합 실험에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–367 of human CD14 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein expressed on mature monocytes, macrophages, and neutrophils.
It functions as a multifunctional lipopolysaccharide receptor and exists in both membrane-bound and soluble forms.
CD14 binds lipopolysaccharides in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), contributing to immune response regulation.
Soluble CD14 (sCD14) can detect structural differences in lipopolysaccharides and aids in neutralization of foreign endotoxins.
Additionally, CD14 interacts with apoptotic cells and influences allergic, inflammatory, and infectious processes.
Alternative splicing produces multiple transcript variants encoding the same isoform.
Malfunctions in CD14 are linked to mycobacterium chelonae infection and croup.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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