Thermo Fisher Scientific Patched1 Monoclonal Antibody (OTI3c2), TrueMAB
Patched1 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 Immunocytochemistry에 최적화됨. Human 샘플에 반응하며, 액상형으로 1 mg/mL 농도. Affinity chromatography로 정제되어 안정적이며, -20°C 보관 권장.
- 카탈로그번호
- TA500122
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3c2 |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 122–436 of human Patched1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full-length sequences and biological validity cannot be determined currently.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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