Thermo Fisher Scientific NOTUM Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal NOTUM 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer와 0.02% sodium azide 포함. 냉장 또는 -20°C 장기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the amino terminus of human NOTUM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155016 |
Product Specific Information
- A suggested positive control is human kidney tissue lysate.
- PA5-20788 can be used with blocking peptide PEP-0902.
Target Information
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, related to plant pectin acetylesterases of the α/β-hydrolase superfamily.
The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing a feedback control mechanism in which Wg modifies its own gradient distribution.
In vertebrates, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling. A single ortholog of Notum exists in the mouse and human genome, implying that a similar regulatory mechanism may exist in vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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