Thermo Fisher Scientific TMC6 Polyclonal Antibody
Rabbit polyclonal antibody against human TMC6 protein. Suitable for Western blot applications. Lyophilized form with 0.85 mg/mL concentration. Shipped at room temperature and stored at -20°C. For research use only.
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Applications
- Western Blot (WB): Tested dilution 1:800
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide CGPFRTLDTMYEAGR, corresponding to amino acid residues 681–695 of human TMC6 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.85 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2736707 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
TMC6 interacts with and forms a complex with the zinc transporter SLC30A1, localizing to the endoplasmic reticulum, nuclear membrane, and Golgi apparatus.
Inactivation of the TMC6 gene is implicated in epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3.
TMC6 encodes integral membrane proteins predicted to form transmembrane channels with 10 transmembrane domains and 2 leucine zipper motifs.
Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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