Thermo Fisher Scientific TMEM38A Polyclonal Antibody
TMEM38A 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Lyophilized 형태로 제공되며, 재구성 후 -20°C 보관. 근육 및 신경 조직 내 TRIC 채널 연구에 적합한 연구용 항체.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200 | - |
| Immunohistochemistry (IHC) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259–274 of rat TMEM38A |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.9 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736709 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
TMEM38A and TMEM38B are trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues.
Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, with cardiac myocytes displaying severe dysfunction in SR Ca²⁺ handling, weakened Ca²⁺ release, and reduced K⁺ permeability.
These findings indicate that TRIC cation channels act as counter-ion channels functioning in synchronization with Ca²⁺ release from intracellular stores.
TMEM38A and TMEM38B can also interact with junctophilin proteins to support efficient ryanodine receptor-mediated Ca²⁺ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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