Thermo Fisher Scientific CASP4 Monoclonal Antibody (OTI9F6), TrueMAB
Human CASP4 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도로 사용 가능. 세포사멸 관련 연구용으로 적합하며, 보존제 무첨가 PBS 버퍼에 안정화됨.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9F6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 81–270 of human CASP4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a key role in the execution phase of cell apoptosis.
Caspases exist as inactive proenzymes and are activated by proteolytic cleavage at conserved aspartic residues, forming a heterodimeric enzyme.
CASP4 can cleave and activate its own precursor as well as the caspase-1 precursor. Overexpression induces apoptosis.
Alternative splicing produces distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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