Thermo Fisher Scientific SIRP alpha Monoclonal Antibody (MRC OX-41)
SIRP alpha (CD172a) 단백질을 인식하는 마우스 단클론 항체로, WB, IHC, Flow Cytometry 등 다양한 응용 가능. 마우스 및 랫트 반응성. 비결합형 액상 형태로 8 mg/mL 농도. 세포 신호 조절 및 면역학 연구용.
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Thermo Fisher Scientific SIRP alpha Monoclonal Antibody (MRC OX-41)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:20–1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MRC OX-41 |
| Immunogen | Rat peritoneal macrophages |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 8 mg/mL |
| Storage Buffer | Ascites |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_561415 |
Additional Formats
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on myeloid cells including granulocytes, dendritic cells, macrophages, mast cells, and hematopoietic stem cells.
It acts as a substrate for several activated tyrosine kinases (EGFR, PDGFR, src, insulin receptor) and negatively regulates receptor tyrosine kinase-coupled signaling pathways.
Binding of SIRP alpha to CD47 induces phosphorylation of ITIMs and recruitment of phosphatases SHP-1 and SHP-2, regulating processes such as inhibition of macrophage phagocytosis and activation of T cells and dendritic cells.
SIRP alpha influences responses to serum, growth factors, insulin, oncogenes, and cell adhesion, playing a role in physiological and pathological processes.
Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of tumor cells.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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