Thermo Fisher Scientific GUCY1B2 (soluble) Monoclonal Antibody (GC25)
인간 GUCY1B2 단백질의 베타 서브유닛을 인식하는 마우스 모노클로날 항체입니다. Western blot, IHC, ELISA 등 다양한 어세이에 사용 가능합니다. Protein A 정제, PBS 버퍼에 0.09% sodium azide 포함. 4°C 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GC25 |
| Immunogen | Recombinant full-length protein: human soluble guanylate cyclase α1β1 heterodimer |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.7 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_559363 |
Product Specific Information
MA1-23047 detects the beta subunit of human soluble guanylate cyclase.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase:
- Soluble form (sGC or GCS): Acts as a receptor for nitric oxide (NO).
- Membrane-bound form (GC): Serves as a peptide hormone receptor.
sGC is a cGMP-synthesizing enzyme and the major receptor for NO, playing a key role in smooth muscle contractility, platelet reactivity, and neurotransmission. It is a heme-containing heterodimer composed of a 72 kDa alpha subunit and a 65 kDa beta subunit. The heme moiety mediates NO activation and can also bind carbon monoxide, which weakly stimulates the enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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