Thermo Fisher Scientific PSMA1 Monoclonal Antibody (OTI6C4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:250

Product Specifications

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in diverse cellular processes such as metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, and transcription.
The ubiquitin-proteasome pathway deconstructs most cytosolic and nuclear proteins in eukaryotic cells, while others are degraded via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (approximately 31 subunits), barrel-shaped molecular complex (~2.5 MDa). It consists of a 20S proteolytic core complex capped by one or two 19S regulatory subunits, which recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core.
An enzymatic cascade mediates the attachment of multiple ubiquitin molecules to lysine residues of target proteins.
Defects in the ubiquitin-proteasome pathway are associated with several genetic diseases, including cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.