Thermo Fisher Scientific TAGLN2 Monoclonal Antibody (OTI7A5), TrueMAB
TAGLN2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 적합. Human 시료 반응성. Affinity chromatography로 정제된 액상 형태이며, PBS/BSA/glycerol buffer에 보존. 연구용 전용 시약.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A5 |
| Immunogen | Full length human recombinant protein of human TAGLN2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transgelin (also designated SM22alpha) is abundantly expressed in smooth muscle cells.
Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is expressed in smooth muscle cells and by peritoneal B-1 cells.
The human transgelin-2 gene (TAGLN2), located on chromosome 1q23.1–q25, encodes a 199 amino acid protein containing a calponin-like repeat and a calponin-homology (CH) domain.
Transgelin-2 may function similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac, and skeletal muscle, but later restricted to vascular and visceral smooth muscle cells with low heart expression.
Downregulation of transgelin has been observed in several transformed cell lines, suggesting it may serve as an early indicator of transformation onset.
Transgelin binds actin, causing actin fibers to gel within minutes of binding, with a binding ratio of 1:6 actin monomers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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