Thermo Fisher Scientific BID Recombinant Rabbit Monoclonal Antibody (005)
인간 BID 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체입니다. Western blot, ICC/IF, ELISA에 적합하며, 높은 특이성과 재현성을 제공합니다. 보존제가 없으며 장기 보관 시 -20°C에서 냉동 보관을 권장합니다.
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Thermo Fisher Scientific BID Recombinant Rabbit Monoclonal Antibody (Clone 005)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 005 |
| Immunogen | Recombinant Human BID protein (Met1–Asp195) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784985 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to prevent contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and the best clones are selected for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader target recognition due to the large rabbit immune repertoire
This antibody has specificity for Human BID.
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It is a member of the BCL-2 family of cell death regulators and mediates mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the C-terminal fragment translocates to mitochondria, triggering cytochrome c release and apoptosis.
BID typically exists in an inactive cytosolic form and becomes activated by caspase 8 upon TNF-alpha or Fas ligand stimulation. The cleaved p15 fragment of BID translocates to mitochondria and initiates apoptosis, serving as a molecular link between caspase 8 activation and mitochondrial death pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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