Thermo Fisher Scientific CD271 (NGF Receptor) Monoclonal Antibody (ME20.4), APC, eBioscience

Thermo Fisher Scientific CD271 (NGF Receptor) Monoclonal Antibody (ME20.4), APC, eBioscience

Applications

• Immunohistochemistry (IHC)
  • Tested dilution: 정보 없음
  • View 1 publication
• Flow Cytometry (Flow)
  • Tested dilution: 5 µL (0.25 µg)/test
  • View 2 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• PE
• Super Bright 436
• Super Bright 600
• Request custom conjugation

Product Specific Information

The monoclonal antibody ME20.4 recognizes CD271, a 75 kDa, type I transmembrane protein belonging to the low-affinity neurotrophin receptor and TNF receptor superfamily.
CD271 is expressed by neurons, Schwann cells, melanocytes, mesenchymal stem/stromal cells, neural crest stem cells, astrocytes, oligodendrocytes, and certain lymphoid cells including follicular dendritic cells.
It binds ligands NGF, BDNF, NTF3, and NTF4, and contains a death domain regulating apoptosis and cell proliferation through TRAF2, TRAF4, TRAF6, PTPN13, and RANBP9.

The ME20.4 antibody recognizes human, non-human primate, mouse, rat, sheep, rabbit, cat, dog, and pig CD271.

Applications Reported: Flow cytometric analysis, western blotting, microscopy.
Applications Tested: Pre-titrated and tested by flow cytometry using stimulated HEK-293T cells.
Recommended use: 5 µL (0.25 µg) per test (final volume 100 µL, 10⁵–10⁸ cells/test).

Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser

Target Information

Neurotrophic factors regulate survival, differentiation, and maintenance of neurons and other neural crest-derived cells.
Antibodies specific for NGFR p75 aid in detection and characterization of NGFR p75, enhancing understanding of neuronal development, plasticity, and repair mechanisms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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