Thermo Fisher Scientific FAM21A Polyclonal Antibody
Rabbit polyclonal antibody against human FAM21A protein. Validated for IHC(P) and ICC/IF applications. Unconjugated form purified by antigen affinity chromatography. Supplied in PBS with glycerol and sodium azide for stable storage. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human FAM21A. Recombinant protein control fragment (Product #RP-105638) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663621 |
Product Specific Information
Immunogen sequence:
SVERTKPKAKI AENPANPPVG GKAKSPMFPA LGEASSDDDL FQSAKPKPAK KTNPFPLLED EDDLFTDQKV KKNE
Highest antigen sequence identity to the following orthologs:
- Mouse: 51%
- Rat: 59%
Target Information
Acts as a component of the WASH core complex, regulating actin polymerization at endosome surfaces. Involved in endosome tubule fission and sorting, mediating recruitment of WASH core complex via phospholipid and VPS35 binding. Promotes localized F-actin polymerization for vesicle scission.
Binds phospholipids including PtdIns-(4)P, PtdIns-(5)P, and PtdIns-(3,5)P2.
Participates in endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo such as GLUT1.
Required for association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 and for endosomal recruitment of CCC and retriever complex subunits.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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