Thermo Fisher Scientific ZIPK Polyclonal Antibody
ZIPK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF, ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human DAPK3 (NP_0013391) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805955 |
Product Specific Information
Immunogen sequence:
MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS SSRRGVSREE IEREVNILRE IRHPNIITLH DIFENKTDVV LILELVSGGE
Positive Samples: Mouse brain, mouse lung, rat brain
Cellular Location: Cytoplasm, Nucleus
Target Information
DAPK3 is a serine/threonine kinase functionally linked to cell motility, smooth muscle contractility, and cell death processes. DAPK3, encoded by ZIPK, is a component of desmosomes and the epidermal cornified envelope in keratinocytes. The N-terminal domain interacts with the plasma membrane, while the C-terminus interacts with intermediate filaments. Through its rod domain, it forms complexes with envoplakin, potentially linking the cornified envelope and desmosomes. AKT1/PKB, a kinase involved in growth and survival signaling, interacts with DAPK3, suggesting a role in AKT1-mediated localization and signaling.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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