Thermo Fisher Scientific CD46 Monoclonal Antibody (M177), FITC
CD46 단백질을 인식하는 M177 클론의 FITC 결합 단일클론 항체. Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능. 인간 시료 반응성, Protein G 정제, PBS/BSA 완충액, 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay (Functional) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M177 |
| Immunogen | Purified MCP |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_3093263 |
Product Specific Information
The monoclonal antibody M177 reacts with the SCR2 domain of CD46.
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments. It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction.
CD46 also serves as a receptor for several human pathogens (bacteria and viruses), and its ligation alters T lymphocyte polarization toward antigen-presenting or target cells, modulating lymphocyte function.
Additionally, CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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