Thermo Fisher Scientific SOCS3 Monoclonal Antibody (OTI6C12), TrueMAB
SOCS3 단백질을 인식하는 마우스 모노클로날 항체로, Western blot과 Immunocytochemistry에 적합합니다. 인간 SOCS3 전장 재조합 단백질을 면역원으로 사용하였으며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C12 |
| Immunogen | Full length human recombinant protein of human SOCS3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SOCS (Suppressor of Cytokine Signaling) proteins negatively regulate cytokine receptor signaling through a family of SH2 domain-containing adaptor molecules.
There are eight known SOCS family members: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS.
Each SOCS protein consists of an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif.
SOCS proteins form a classical negative feedback loop that modulates cytokine signal transduction via STAT-induced transcriptional mechanisms.
Transcription of SOCS genes occurs rapidly in response to cytokines, and each member inhibits signaling through distinct pathways.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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