Thermo Fisher Scientific beta-2 Adaptin Recombinant Rabbit Monoclonal Antibody (9W4U6)
Beta-2 Adaptin 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot과 ELISA에 적합. 인간, 마우스, 랫트 반응성. HEK293 세포 발현, Protein A 정제, 액상 형태. 연구용으로만 사용 가능.
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- MA555356
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9W4U6 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 752–951 of human AP2B1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.75 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
MEMNFTNKAL QHMTDFAIQF NKNSFGVIPS TPLAIHTPLM PNQSIDVSLP LNTLGPVMKM EPLNNLQVAV KNNIDVFYFS CLIPLNVLFV EDGKMERQVF LATWKDIPNE NELQFQIKEC HLNADTVSSK LQNNNVYTIA KRNVEGQDML YQSLKLTNGI WILAELRIQP GNPNYTLSLK CRAPEVSQYI YQVYDSILKN
Target Information
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin-coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors, which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors, AP1 and AP2.
AP1 is associated with clathrin-coated vesicles at the trans-Golgi network, while AP2 is associated with endocytic clathrin-coated vesicles at the plasma membrane and interacts with Shc and EGF receptor.
AP2 is composed of four subunits: two separate ~100 kDa gene products (alpha and beta adaptin) with similar domain structures, and ~50 and ~17 kDa subunits. There are two alpha-adaptin genes, alpha A and alpha C, which show tissue-specific expression patterns.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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