Thermo Fisher Scientific IL-22 Polyclonal Antibody
IL-22 단백질을 인식하는 고특이적 Rabbit Polyclonal Antibody로, WB, IHC, ELISA 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 순도와 재현성 제공. 인간 IL-22에 반응하며, 연구용으로 세포 신호전달 및 염증 연구에 활용 가능.
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Thermo Fisher Scientific IL-22 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| ELISA | 1:1,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 1–97 of IL-22 (Uniprot ID: Q9GZX6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552105 |
Product Specific Information
- Recommended positive control: Molt-4
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN–IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
It is mainly produced by activated T cells and NK cells. The IL-22 gene is located on chromosome 12q and structurally related to IL-10.
IL-22 acts via a heterodimeric receptor complex composed of IL-22R1 and IL-10R2, activating the JAK-STAT signaling pathway.
A soluble receptor form, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as skin, digestive and respiratory epithelial cells, hepatocytes, and keratinocytes.
It functions as an effector cytokine of the Th17 lineage, regulating innate immunity genes in the skin alongside IL-17A and IL-17F.
IL-22 induces acute phase reactants and antimicrobial proteins, enhances keratinocyte mobility, and is upregulated during chronic inflammation.
It plays a critical role in host defense against extracellular pathogens and promotes wound-healing responses.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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