Thermo Fisher Scientific IL-22 Polyclonal Antibody

Thermo Fisher Scientific IL-22 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: Molt-4
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN–IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
It is mainly produced by activated T cells and NK cells. The IL-22 gene is located on chromosome 12q and structurally related to IL-10.
IL-22 acts via a heterodimeric receptor complex composed of IL-22R1 and IL-10R2, activating the JAK-STAT signaling pathway.
A soluble receptor form, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as skin, digestive and respiratory epithelial cells, hepatocytes, and keratinocytes.
It functions as an effector cytokine of the Th17 lineage, regulating innate immunity genes in the skin alongside IL-17A and IL-17F.
IL-22 induces acute phase reactants and antimicrobial proteins, enhances keratinocyte mobility, and is upregulated during chronic inflammation.
It plays a critical role in host defense against extracellular pathogens and promotes wound-healing responses.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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