Thermo Fisher Scientific ATP2C1 Polyclonal Antibody

Thermo Fisher Scientific ATP2C1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa
• Predicted reactivity: Mouse (96%), Rat (97%), Rhesus Monkey (99%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA1), belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin.
Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and shows a lower maximal turnover rate for Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation.
Recent evidence suggests ATP2C1 is a key regulator of IGF1R processing in tumor progression in basal breast cancers.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)