Thermo Fisher Scientific Dectin 1 Monoclonal Antibody (GE2), FITC
인간 Dectin-1(beta-glucan receptor)을 인식하는 GE2 클론의 마우스 단클론 항체. FITC 형광 표지로 유세포 분석에 적합. Protein A 정제, PBS/BSA 완충액에 보관. 단기 4°C, 장기 -20°C 저장. 연구용으로만 사용.
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Thermo Fisher Scientific Dectin 1 Monoclonal Antibody (GE2), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat–1:10
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GE2 |
| Immunogen | NIH3T3 cells expressing full-length Beta-glucan receptor |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles; store in the dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538187 |
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-human Dectin-1 antibody, clone GE2, recognizes human Dectin-1 (beta-glucan receptor, betaGR), a member of the C-type lectin domain family.
Target Information
CLEC7A (Dectin-1) is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, predominantly expressed on myeloid cells. It is a small type II membrane glycoprotein receptor with an extracellular C-type lectin-like domain and a cytoplasmic ITAM motif.
CLEC7A functions as a pattern-recognition receptor for beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, playing a key role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, inducing an oxidative burst via reactive oxygen species formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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