Thermo Fisher Scientific Dectin 1 Monoclonal Antibody (GE2), PE
인간 Dectin-1을 인식하는 Mouse IgG1 단클론 항체로, PE 형광 접합 형태로 제공됩니다. Flow Cytometry에 적합하며, 565/576 nm의 여기/방출 특성을 가집니다. NIH3T3 세포 유래 항원으로 제작되었으며, 단백질 G로 정제된 리오필라이즈 형태입니다.
- 카탈로그번호
- MA516695
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Dectin 1 Monoclonal Antibody (GE2), PE
Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat
Publications: N/A
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GE2 |
| Immunogen | NIH3T3 cells expressing full length Beta-glucan receptor |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA, 5% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538189 |
Additional Formats
Product Specific Information
- Reconstitute with 1 mL of distilled water.
- After reconstitution, store undiluted at 4ºC in the dark.
- For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
- Mouse anti-Human Dectin-1 antibody, clone GE2 recognizes human Dectin-1 (beta-glucan receptor, betaGR), a C-type lectin domain family member.
Target Information
CLEC7A (Dectin-1) is a C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily member predominantly expressed on myeloid cells.
It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic ITAM motif.
CLEC7A acts as a pattern-recognition receptor that binds beta-1,3- and beta-1,6-linked glucans from fungi and plants, playing a key role in innate immune response.
Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering an oxidative burst through reactive oxygen species formation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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