Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (MIL12), FITC

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• Unconjugated (MA5-28520)
• PE (MA5-16850)
• Request custom conjugation (Form link)

Product Specific Information

Mouse anti-Pig wCD8 alpha antibody, clone MIL12 recognizes an epitope on the alpha chain of porcine wCD8.

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family. It plays a key role in signal transduction, T cell differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules. CD8α is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Engagement of MHC-I/peptide complexes on antigen-presenting cells triggers Lck recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are essential for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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