Thermo Fisher Scientific PLOD2 Monoclonal Antibody (OTI7G5), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The PLOD2 gene encodes a membrane-bound homodimeric enzyme localized to the cisternae of the rough endoplasmic reticulum.
This enzyme, requiring iron and ascorbate as cofactors, catalyzes the hydroxylation of lysyl residues in collagen-like peptides.
The hydroxylysyl groups serve as attachment sites for carbohydrates in collagen, contributing to the stability of intermolecular crosslinks.
Deficiency in lysyl hydroxylase activity has been linked to Ehlers-Danlos syndrome type VIB, and mutations in this gene are associated with Bruck syndrome.
Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.