Thermo Fisher Scientific LYVE1 Polyclonal Antibody
Rabbit polyclonal antibody against LYVE1 for IHC and ICC/IF applications. Reacts with human and mouse, predicted to react with cow. Supplied as liquid, 0.3 mg/mL concentration, stored at 4°C short term or -20°C long term. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Mouse LYVE1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10974152 |
Product Specific Information
This antibody is predicted to react with cow based on sequence homology.
Target Information
LYVE1 (Lymphatic vessel endothelial hyaluronan receptor 1) is a major receptor for hyaluronan (HA) on lymph vessel walls. It encodes a 322-residue type I integral membrane glycoprotein with 41% similarity to the CD44 HA receptor and contains a single Link module, the prototypic HA binding domain. LYVE1 binds both soluble and immobilized HA, but unlike CD44, it colocalizes with HA on the luminal face of lymph vessels and is absent from blood vessels. It serves as a specific marker for lymphatic endothelium and is implicated in the regulation of leukocyte and tumor cell trafficking to lymph nodes. LYVE1 dysfunction has been associated with Complete Androgen Insensitivity Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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