Thermo Fisher Scientific TAS2R16 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous PubMed (Misc)

• Publications: View 2 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: TAS2R16.

Target Information

This gene encodes a member of a family of candidate taste receptors belonging to the G protein-coupled receptor superfamily. These receptors are expressed by taste receptor cells of the tongue and palate epithelia. Each gene encodes a 7-transmembrane receptor protein functioning as a bitter taste receptor.

The TAS2R16 gene is clustered with other candidate taste receptor genes on chromosome 7 and is genetically linked to loci influencing bitter perception. It acts as a gustducin-coupled receptor involved in bitter compound detection in the oral cavity and gastrointestinal tract, signaling through PLCB2 and TRPM5 channels. Expressed in a subset of gustducin-positive taste receptor cells of the tongue. The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism and confers bitter perception of salicin to non-taster mice.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.