Thermo Fisher Scientific MBD4 Polyclonal Antibody
Human MBD4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. DNA 메틸화 및 탈메틸화 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MBD4 (Product #RP-101998) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2643787 |
Product Specific Information
Immunogen sequence:
LQNQSNNSNW NLRTRSKCKK DVFMPPSSSS ELQESRGLSN FTSTHLLLKE DEGVDDVNFR KVRKPKGKVT ILKGIPIKKT KKGCRKSCSG FVQSDSKRES VCNKADAESE PVAQKSQLDR TVCISDAGAC GETLSVTSEE N
Antigen sequence identity:
- Mouse: 48%
- Rat: 45%
Target Information
DNA methylation, the addition of methyl groups to cytosine bases in CpG dinucleotides, regulates gene expression and is crucial for proper development. MBD4 (also known as MED1) is a mammalian demethylase with a methyl-CpG-binding domain (MBD) and is involved in DNA demethylation by cleaving methyl groups as methanol.
MBD family proteins (MeCP2, MBD1, MBD2, MBD3, MBD4) have distinct roles in transcriptional repression and DNA methylation signaling. MBD4 shows homology to bacterial DNA N-glycosylases/lyases and is sometimes mutated in microsatellite unstable tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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