Thermo Fisher Scientific Phospho-BCL9L (Ser915) Polyclonal Antibody
인간, 마우스, 랫트에서 Ser915 인산화된 BCL9L 단백질을 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합하며, 고순도 크로마토그래피로 정제된 액상 형태. Wnt 신호전달 및 암 관련 연구용으로 최적화.
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Thermo Fisher Scientific Phospho-BCL9L (Ser915) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL9L (Accession Q86UU0), corresponding to amino acid residues around phosphorylated Ser915 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816050 |
Product Specific Information
Antibody detects endogenous levels of BCL9L only when phosphorylated at Ser915.
Target Information
Bcl9L, a homolog of Bcl9, was initially identified through bioinformatics screening. It is expressed in fetal brain, adult lung, eye, and prostate, as well as in several tumor types including pancreatic and prostate cancers.
Bcl9L interacts with beta-catenin, a key component of the Wnt signaling pathway, and is required for enhanced beta-catenin–TCF-mediated transcription in colorectal tumor cells, possibly by facilitating beta-catenin nuclear translocation.
Studies indicate that Bcl9L expression correlates with high nuclear grade cancer phenotypes and ErbB2/HER-2 expression in breast cancers, suggesting its involvement in other cancer types.
Additionally, Bcl9L plays a critical role in Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas, associated with tumor invasion, metastasis, and therapy resistance.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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