Thermo Fisher Scientific TCF12 Polyclonal Antibody
TCF12 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 최적화됨. 인간 시료에 반응하며, Jurkat 세포를 양성 대조군으로 사용. 고순도 항원 친화 크로마토그래피 정제 및 안정적 액상 형태 제공.
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Thermo Fisher Scientific TCF12 Polyclonal Antibody
Applications
- Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TCF12 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736686 |
Product Specific Information
- Positive Control: Jurkat, Jurkat nuclear extract
- Predicted Reactivity: Mouse (89%), Rat (88%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG.
TCF12 is expressed in many tissues, including skeletal muscle, thymus, B- and T-cells, and may regulate lineage-specific gene expression through heterodimer formation with other bHLH E-proteins.
Together with E2A, TCF12 blocks thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation.
Recent studies indicate TCF12 is essential for invariant natural killer T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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