Thermo Fisher Scientific ASGR1 Recombinant Rabbit Monoclonal Antibody (114)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:250–1:1,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody specifically recognizes Mouse ASGPR1/ASGR1.

Target Information

The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (~42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on hepatocyte surfaces in a polar manner—present on sinusoidal and lateral plasma membranes, but not on bile canalicular membranes.
Mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.

The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. Monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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