Thermo Fisher Scientific CEA Polyclonal Antibody
Thermo Fisher Scientific의 CEA Polyclonal Antibody는 인간 CEA(CD66e)에 반응하는 토끼 IgG 항체로, WB, IHC, Flow Cytometry에 사용 가능. 고순도 정제 및 안정한 액상 형태로 제공되며, 종양 표지자 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 400–429 amino acids from the central region of human CEA (CD66e, CEACAM5, UniProt ID: P06731-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.44 mg/mL |
| Purification | Protein A, Affinity chromatography, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2077583 |
Target Information
CEA (Carcino Embryonic Antigen, CD66e) is synthesized during development in the fetal gut and re-expressed in increased amounts in intestinal carcinomas and several other tumors. CEA is a member of the carcinoembryonic antigen family, part of the immunoglobulin supergene family, consisting of a single N domain and six immunoglobulin constant-like domains (A1, A2, A3, B1, B2, B3).
Antibodies to CEA help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (60–70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell adhesion molecule detected on leukocytes, epithelia, and endothelia. It mediates cell adhesion via homophilic and heterophilic interactions and plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune response modulation. Multiple transcript variants exist, though not all are fully defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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