Thermo Fisher Scientific PTPN2 Polyclonal Antibody
Thermo Fisher Scientific의 PTPN2 Polyclonal Antibody는 인간 PTPN2 단백질을 인식하는 토끼 폴리클로날 항체입니다. WB, IHC, ICC/IF 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTPN2 (Recombinant protein control fragment Product # RP-90507) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789674 |
Product Specific Information
Immunogen sequence:
DDINIKQVLL NMRKYRMGLI QTPDQLRFSY MAIIEGAKCI KGDSSIQKRW KELSKEDLSP AFDHSPNKIM TEKYNGNRIG LEEEKLTGDR CTGLSSKMQD TMEENSESAL RKRIREDRKA TTAQKVQQMK QRLNENERK
Target Information
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal splice variants with different subcellular localizations.
- The 45 kDa isoform is nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors and stress.
- The 48 kDa isoform is found in the endoplasmic reticulum and has distinct physiological substrates.
TC-PTP is expressed in many tissues, particularly in hematopoietic cells. Knockout mice lacking TC-PTP die 3–5 weeks after birth due to erythropoietic and lymphopoietic deficits, indicating its essential role in bone marrow maturation. TC-PTP dephosphorylates multiple phosphoproteins, including p52 Shc and receptors for EGF, insulin, and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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