Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI3A6), TrueMAB
ITFG2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 Immunocytochemistry에 사용 가능. HEK293T에서 생산된 인간 ITFG2 전장 단백질을 면역원으로 함. TrueMAB 형식의 비결합 액상 항체로, 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A6 |
| Immunogen | Full length human recombinant protein of human ITFG2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.36 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
As part of the KICSTOR complex, ITFG2 functions in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, allowing interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of RAG GTPases and negatively regulates mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively localized to lysosomes and activated. The complex may also regulate mTORC1 in response to glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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